Thursday, April 08, 2010
Wednesday, January 31, 2007
This blog has moved
The "advanced medical technologies" blog of MedMarket Diligence's Patrick Driscoll has moved to a new address in the blogosphere: http://mediligence.com/blog.
Please visit us, and thank you Blogger.
Tags: medtech
Please visit us, and thank you Blogger.
Tags: medtech
Tuesday, January 09, 2007
Amniotic stem cells good, but not embryonic replacement
As reported in the Washington Post and other sources, researchers at the Institute for Regenerative Medicine at Wake Forest University and Children's Hospital (Boston) have shown that stem cells from amniotic fluid can be differentiated into brain cells, bone cells, muscle, fat, blood vessels and liver cells, demonstrating the kind of pluripotentiality that has previously marked one of the real distinctions between embryonic and adult stem cells. Moreover, the amniotic stem cells demonstrated a kind of stability (resisting formation of tumors) that is better than embryonic stem cells.
Quick to pounce on and deflate the balloon of embryonic stem cells as the only solution, some opponents of embryonic stem cell research (e.g., Richard Doerflinger of the U.S. Conference of Catholic Bishops, who notes,"This is wonderful news," for offering the benefits of stem cells without destroying embryos). They have a valid point, but one that is limited by the fact that no stem cell type is likely to be perfect for all applications and that in reality a continuum of stem cell types exists, with a comparable spectrum of advantages. George Daley of Harvard, notes that amniotic stem cells "are not a replacement for embryonic stem cells."
As Charles Darwin said, "a scientific man ought to have no wishes, no affections, -- a mere heart of stone." The science of determining the clinical application of different stem cell types needs to be carried out in a way that is less fraught with hope and expectation of specific outcomes for or against the value of embryonic stem cells for specific applications. The field remains characterized more by wishes and affections than science.
Tags: medtech, embryonic, stem-cells
Quick to pounce on and deflate the balloon of embryonic stem cells as the only solution, some opponents of embryonic stem cell research (e.g., Richard Doerflinger of the U.S. Conference of Catholic Bishops, who notes,"This is wonderful news," for offering the benefits of stem cells without destroying embryos). They have a valid point, but one that is limited by the fact that no stem cell type is likely to be perfect for all applications and that in reality a continuum of stem cell types exists, with a comparable spectrum of advantages. George Daley of Harvard, notes that amniotic stem cells "are not a replacement for embryonic stem cells."
As Charles Darwin said, "a scientific man ought to have no wishes, no affections, -- a mere heart of stone." The science of determining the clinical application of different stem cell types needs to be carried out in a way that is less fraught with hope and expectation of specific outcomes for or against the value of embryonic stem cells for specific applications. The field remains characterized more by wishes and affections than science.
Tags: medtech, embryonic, stem-cells
Tuesday, January 02, 2007
Medtech Startups: Stealth, Location, and Platform Tech
Medical Technology Startups Identified in the December 2006 MedMarkets (subscribers only).
In the December 2006 issue of MedMarkets, I note in my MedMarket Outlook column the common tendencies in the formation of medical technology startups in 2006. It should come as no surprise that central to many (though certainly not all) were the premises of stealth (staying under the radar), location (where are startups concentrated, as if it should be any surprise), and platform technologies, among others.
Here, for reference (or late Christmas present), are the companies identified in the December issue.
In the December 2006 issue of MedMarkets, I note in my MedMarket Outlook column the common tendencies in the formation of medical technology startups in 2006. It should come as no surprise that central to many (though certainly not all) were the premises of stealth (staying under the radar), location (where are startups concentrated, as if it should be any surprise), and platform technologies, among others.
Here, for reference (or late Christmas present), are the companies identified in the December issue.
| Company | Principal(s) | Location | Product/Technology | Founded |
| Carticept Medical, Inc. | (Domain Associates, New Enterprise Associates) | Alpharetta, GA | Development and sales of therapeutically related medical devices | 2005 |
| Forcept, Inc. | John Maroney | Menlo Park, CA | Assisted cautery/cutting systems for performing transvaginal hysterectomy | 2005 |
| Internal Fixation Systems, Inc. | Steve Hernandez | Medley, FL | Orthopedic implants (e.g., bone screws) | 2006 |
| I-Therapeutix, Inc. | William H. Ransone II | Waltham, MA | Hydrogel sealant for use in ophthalmic surgery | 2006 |
| iCardiac Technologies, Inc. | Mikael Totterman, CEO | Rochester, NY | ECG-based cardiac diagnostics and medical devices | 2006 |
| NBI Development, Inc. | Undisclosed | Chicago, IL | Spinal neuromodulation devices | 2006 |
| Optmed, LLC | Alain Klapholz | New York, NY | Developing "innovative medical technologies" | 2006 |
| Safe Surgery Technologies LLC | David Michelson | Cheyenne, WY | Capsulotomy cutting device | 2006 |
| TriReme Medical, Inc. | Eitan Constantino | Pleasanton, CA | Apparatus and methods for delivering prostheses to luminal bifurcations | 2005 |
| Vertebral Technologies, Inc. | Jeffrey Felt, CEO | Minnetonka, MN | Biocompatible polymers for joint restoration in the spine | 2005 |
Carticept Medical, Inc. (Alpharetta, GA; http://carticept.com [under construction])
Forcept, Inc. (Menlo Park, CA; no URL)
Internal Fixation Systems, Inc. (Medley, FL; no URL)
I-Therapeutix, Inc. (Waltham, MA; http://itherapeutix.com)
iCardiac Technoloigies, Inc. (Rochester, NY; http://icardiac.com)
NBI Development, Inc. (Chicago, IL; http://nbidevelopment.com [under construction])
Optmed, LLC (New York, NY; http://optmed.net)
Safe Surgery Technologies LLC (Cheyenne, WY; no URL)
TriReme Medical, Inc. (Pleasanton, CA; no URL)
Vertebral Technologies, Inc. (Minnetonka, MA; no URL)
Thursday, December 07, 2006
FDA Panel Assesses Drug-Eluting Stents and Clotting
Questions about whether the risks of clotting, heart attacks and death are higher for patients with drug-eluting stents compared bare stents are the subject of a two-day panel by the FDA. The questions center on whether and how long patients with the drug-eluting stents should stay on anti-clotting drugs such as Plavix. In a worst case scenario, the elevated risks, which the FDA does believe exists, could ultimately sabotage a $5 billion market for the devices.
Principal players (with a bevy of newcomers waiting in the wings) Boston Scientific and Johnson & Johnson have different spins on the risk. Boston Scientific "acknowledges a slight increase in clotting associated with its drug-coated stent, the Taxus," but the company asserts that there is no corresponding increased risk of heart attack or death. Johnson & Johnson argues that the risk of clotting, heart attack or death is equivalent for drug-eluting and bare stents.
The question of increased risk of clotting will certainly influence approvals of pending drug-eluting stents from Medtronic, Abbott and others.
Detailed coverage of the drug-eluting stent market is provided in the October 2006 issue of MedMarkets (subscribers).
Tags: medtech, stents
Principal players (with a bevy of newcomers waiting in the wings) Boston Scientific and Johnson & Johnson have different spins on the risk. Boston Scientific "acknowledges a slight increase in clotting associated with its drug-coated stent, the Taxus," but the company asserts that there is no corresponding increased risk of heart attack or death. Johnson & Johnson argues that the risk of clotting, heart attack or death is equivalent for drug-eluting and bare stents.
The question of increased risk of clotting will certainly influence approvals of pending drug-eluting stents from Medtronic, Abbott and others.
Detailed coverage of the drug-eluting stent market is provided in the October 2006 issue of MedMarkets (subscribers).
Tags: medtech, stents
Wednesday, December 06, 2006
Orthopedic Biomaterials Global Market
Orthopaedic devices are a major contributor to the global medical device market, accounting for almost $26 billion in 2006, and with a growth rate that reflects growth in the medical sector overall. The table below gives a market growth projection for the five years 2007-2011.
| | Worldwide Sales | Growth |
| 2006 | 25,764 | -- |
| 2007 | 27,122 | 5.3% |
| 2008 | 28,562 | 5.3% |
| 2009 | 30,989 | 8.5% |
| 2010 | 31,708 | 2.3% |
| 2011 | 33,425 | 5.4% |
| CAGR | 5.3% | |
Orthopaedic Biomaterials
The current valuation of the orthopaedic biomaterials segment is around $5 billion, representing over 17% of the orthopaedic total. It is also estimated that this market segment will grow at 10-12% a year, that is more than double the rate for the overall orthopaedics market. At this rate the biomaterials segment will achieve a value of $9.5 billion by 2011 and will represent 28% of all orthopaedic product sales.
The global market for orthopedic biomaterials is analyzed in a new report from MedMarket Diligence (www.mediligence.com).
Tags: medtech, orthopedic
Thursday, November 30, 2006
Global Growth in Refractive Surgery
Shift in use of refractive types, growth by country...
Refractive surgery is performed using a number of surgical techniques, each designed to minimize the patient’s dependence on eyeglasses and contact lenses. Although there are many options to improve refractive error making it a complex field for the surgeon, while at the same time offering a broad range of options to treat each patient’s unique needs, some approaches will grow at a greater rate while other refractive surgery options will be cannibalized by these faster growing techniques or they will be relegated to serving the needs of niche populations. For those techniques that serve a particular niche population, manufacturers will struggle with how to maintain visibility for these sub-population therapies while ensuring that clinical competence will be maintained at a level to allow the surgeon to deliver the outcomes that are feasible.
Numerous factors come into play as the market for refractive surgery evolves:
The net effect is that custom LASIK will soon constitute a dominant share of refractive procedures.
Globally, the U.S. dominates the market for refractive surgery products, but strong growth is evident in many countries.
Tags: medtech, ophthalmology, refractive, LASIK
Refractive surgery is performed using a number of surgical techniques, each designed to minimize the patient’s dependence on eyeglasses and contact lenses. Although there are many options to improve refractive error making it a complex field for the surgeon, while at the same time offering a broad range of options to treat each patient’s unique needs, some approaches will grow at a greater rate while other refractive surgery options will be cannibalized by these faster growing techniques or they will be relegated to serving the needs of niche populations. For those techniques that serve a particular niche population, manufacturers will struggle with how to maintain visibility for these sub-population therapies while ensuring that clinical competence will be maintained at a level to allow the surgeon to deliver the outcomes that are feasible.
Numerous factors come into play as the market for refractive surgery evolves:
- Clinical Outcomes – documented clinical advantage will not only encourage physicians to embrace new approaches to refractive surgery, it will help clinicians to determine the subset of patients that are most likely to benefit by one technique over another.
- Physician Education – the speed with which surgeons can be trained on the new techniques
- Access – how rapidly will the market adopt the technology that is necessary to perform the procedure and how quickly will the market be penetrated
- Patient Education – the ability of physicians and marketing efforts by manufacturers to inform patients of various options
- Cost – Significant differences in price to the patient as well as cost associated with training and equipment by physicians and ambulatory care centers
- Reimbursement – insurers willingness to pay for such procedures will continue to be a factor in a patient’s decision to undergo refractive surgery
The net effect is that custom LASIK will soon constitute a dominant share of refractive procedures.
Globally, the U.S. dominates the market for refractive surgery products, but strong growth is evident in many countries.
Tags: medtech, ophthalmology, refractive, LASIK
Subscribe to:
Posts (Atom)
